Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives

Marine Drugs

Janice R. Sufrin¹  Steven Finckbeiner¹ 

关键词: adenosylmethionine;    ethylene;    polyamines;    radical SAM;    quorum sensing;   

DOI  :  10.3390/md7030401

来源: mdpi

【 摘 要 】

S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homoserine lactones. Marine organisms produce numerous AdoMet metabolites whose novel structures can be regarded as lead compounds for anti-infective drug design.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland