Efficient Microwave Assisted Syntheses of 2,5-Diketopiperazines in Aqueous Media

Molecules

Lemuel Pérez-Picaso¹  Jaime Escalante¹  Horacio F. Olivo¹ 

[1] ¹Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, 62209 Cuernavaca, Morelos, México ²Medicinal and Natural Products Chemistry, The University of Iowa, Iowa City, IA 52242, USA

关键词: 2;    5-diketopiperazines;    DKPs;    cyclic dipeptides;    microwave irradiation;   

DOI  :  10.3390/molecules14082836

来源: mdpi

【 摘 要 】

Aqueous in situ one-pot N-Boc-deprotection-cyclization of Nα-Boc-dipeptidyl-tert-butyl and methyl esters under microwave irradiation afforded 2,5-diketopiperazines (DKPs) in excellent yields. This protocol is rapid, safe, environmentally friendly, and highly efficient, and showed that the tert-butoxy moiety is also an excellent leaving group for these cyclizations.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.