Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug

Molecules

Carmela Napolitano¹  Martina Scaglianti¹  Emanuela Scalambra¹  Stefano Manfredini¹  Luca Ferraro¹  Sarah Beggiato¹ 

[1] ¹Department of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy

关键词: L-carnitine;    molecular conjugation;    increased brain delivery;    prodrug;    nipecotic acid;   

DOI  :  10.3390/molecules14093268

来源: mdpi

【 摘 要 】

As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.