HCV Animal Models: A Journey of More than 30 Years

Viruses

Philip Meuleman¹ 

关键词: HCV;    animal model;    chimpanzee;    chimeric mice;    uPA-SCID;    hepatitis C;    antiviral therapy;    neutralizing antibodies;   

DOI  :  10.3390/v1020222

来源: mdpi

【 摘 要 】

In the 1970s and 1980s it became increasingly clear that blood transfusions could induce a form of chronic hepatitis that could not be ascribed to any of the viruses known to cause liver inflammation. In 1989, the hepatitis C virus (HCV) was discovered and found to be the major causative agent of these infections. Because of its narrow tropism, the in vivo study of this virus was, especially in the early days, limited to the chimpanzee. In the past decade, several alternative animal models have been created. In this review we review these novel animal models and their contribution to our current understanding of the biology of HCV.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.