Preparation and Characterization of Novel Gellan Gum Hydrogels Suitable for Modified Drug Release

Molecules

Pietro Matricardi¹  Claudia Cencetti¹  Roberto Ria¹  Franco Alhaique¹ 

[1] Department of Drug Chemistry and Technologies, Faculty of Pharmacy, University of Rome “La Sapienza”, Piazzale Aldo Moro 5, 00185, Rome, Italy

关键词: Gellan;    hydrogels;    modified drug release;    rheology;    texture analysis;   

DOI  :  10.3390/molecules14093376

来源: mdpi

【 摘 要 】

Innovative hydrogels obtained by physical and chemical crosslinking of deacylated Gellan gum have been characterized in terms of water uptake, rheological properties and compressibility, and the behaviour of the tested materials, according to the type of the obtained network, is thoroughly discussed. The release from the various gels of loaded model molecules of different steric hindrance was also investigated and the trend of the release profiles has been related to the structures proposed for the physical and the chemical hydrogel.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.