Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers

Molecules

Piotr Polcyn¹  Margarita Jurczak¹  Aleksandra Rajnisz¹  Jolanta Solecka¹ 

[1] ¹Institute of Organic Chemistry PAS, Kasprzaka Str. 44/52 01-224 Warsaw, Poland ²National Institute of Public Health – PZH, Chocimska Str. 24, 00-791 Warsaw, Poland

关键词: dendrimeric peptides;    antimicrobial;    antibiotic resistance;   

DOI  :  10.3390/molecules14103881

来源: mdpi

【 摘 要 】

Novel polyfunctional small amphiphilic peptide dendrimers characterized by incorporation of a new core compounds – tris-amino acids or tetrakis-amino alcohols that originated from a series of basic amino acids – were efficiently synthesized. These new core elements yielded molecules with multiple branching and (+5)/(+6) charge at the 1-st dendrimer generation. Dendrimers exhibited significant antimicrobial potency against Gram(+) and Gram(-) strains involving also multiresistant reference strains (S. aureus ATCC 43300 and E. coli ATCC BAA-198). In addition, high activity against fungi from the Candida genus was detected. More charged and more hydrophobic peptide dendrimers expressed hemolytic properties.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.