A(H5N1) Virus Evolution in South East Asia

Viruses

Ramona Alikiiteaga Gutiérrez¹  Monica Jane Naughtin¹  Srey Viseth Horm¹  Sorn San² 

[1] Institut Pasteur du Cambodge, Virology Unit, 5 Monivong boulevard, PO Box 983, Phnom Penh, Cambodia; E-Mails: [e-mail] (M.J.N.); [e-mail] (S.V.H.);National Veterinary Research Institute (NaVRI)/ Phum Trea, Sals Street # 371, Phnom Penh, Cambodia; E-Mail: [e-mail] (S.S.)

关键词: avian influenza;    H5N1 virus;    evolution;    South East Asia;   

DOI  :  10.3390/v1030335

来源: mdpi

【 摘 要 】

Highly Pathogenic Avian Influenza (HPAI) H5N1 virus is an ongoing public health and socio-economic challenge, particularly in South East Asia. H5N1 is now endemic in poultry in many countries, and represents a major pandemic threat. Here, we describe the evolution of H5N1 virus in South East Asia, the reassortment events leading to high genetic diversity in the region, and factors responsible for virus spread. The virus has evolved with genetic variations affecting virulence, drug-resistance, and adaptation to new host species. The constant surveillance of these changes is of primary importance in the global efforts of the scientific community.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland