An Efficient Method for the N-Bromosuccinimide Catalyzed Synthesis of Indolyl-Nitroalkanes

Molecules

Chun-Wei Kuo¹  Chun-Chao Wang¹  Hu-Lin Fang¹  B. Rama Raju¹  Veerababurao Kavala¹  Pateliya Mujjamil Habib¹ 

[1] Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 116, Taiwan

关键词: indolyl-nitroalkane;    N-bromosuccinimide;    nitroalkenes;    Friedel-Crafts alkylation;   

DOI  :  10.3390/molecules14103952

来源: mdpi

【 摘 要 】

An efficient and practical method for the synthesis of indolyl-nitroalkane derivatives catalyzed by N-bromosuccinimide is described. The generality of this method was demonstrated by synthesizing an array of diverse 3-substituted indole derivatives by the reaction of different β-nitrostyrenes with various substituted indoles. Simple reaction conditions accompanied by good yields of indolyl-nitroalkanes are the merits of this methodology.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.