Robustness in Regulatory Interaction Networks. A Generic Approach with Applications at Different Levels: Physiologic, Metabolic and Genetic

International Journal of Molecular Sciences

Jacques Demongeot¹  Hedi Ben Amor¹  Adrien Elena¹  Pierre Gillois¹  Mathilde Noual² 

[1] Université J. Fourier de Grenoble, TIMC-IMAG, CNRS UMR 5525, Faculté de Médecine, 38700 La Tronche, France; E-Mails:;Université de Lyon, École Normale Supérieure Lyon, LIP, CNRS UMR 5668, 69007 Lyon, France

关键词: robustness in regulatory interaction networks;    attractors;    interaction graph boundary;    interaction graph core;    critical node;    critical edge;    updating mode;    microRNAs;   

DOI  :  10.3390/ijms10104437

来源: mdpi

【 摘 要 】

Regulatory interaction networks are often studied on their dynamical side (existence of attractors, study of their stability). We focus here also on their robustness, that is their ability to offer the same spatiotemporal patterns and to resist to external perturbations such as losses of nodes or edges in the networks interactions architecture, changes in their environmental boundary conditions as well as changes in the update schedule (or updating mode) of the states of their elements (e.g., if these elements are genes, their synchronous coexpression mode versus their sequential expression). We define the generic notions of boundary, core, and critical vertex or edge of the underlying interaction graph of the regulatory network, whose disappearance causes dramatic changes in the number and nature of attractors (e.g., passage from a bistable behaviour to a unique periodic regime) or in the range of their basins of stability. The dynamic transition of states will be presented in the framework of threshold Boolean automata rules. A panorama of applications at different levels will be given: brain and plant morphogenesis, bulbar cardio-respiratory regulation, glycolytic/oxidative metabolic coupling, and eventually cell cycle and feather morphogenesis genetic control.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.