BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas

Cancers

Erica Lana²  Marie-Elisabeth Brun¹  Isabelle Rivals⁵  Janick Selves⁶  Sylvain Kirzin⁶  Andriy P. Lutsyk⁷  Vasily V. Gordiyuk⁴  Frຝéric Bibeau³  Alla Rynditch⁴ 

[1] Institut de Génétique Humaine, CNRS UPR 1142, Montpellier, France; E-Mail:;INSERM U827, Montpellier, France; E-Mail:;CRLC, Montpellier, France; E-Mail:;Department of Functional Genomics, Institute of Molecular Biology and Genetics NASU, Kyiv, Ukraine; E-Mail:;Equipe de Statistique Appliquée, ESPCI ParisTech, Paris, France; E-Mail:;CHU Purpan and INSERM U563, Toulouse, France; E-Mail:;O.O. Bogomoletz National Medical University, Kyiv, Ukraine; E-Mails:

关键词: BAGE;    DNA hypomethylation;    adenomas;    colorectal cancer;    biomarker;    COBRA;   

DOI  :  10.3390/cancers1010003

来源: mdpi

【 摘 要 】

We showed earlier that BAGE (B melanoma antigen) loci are hypermethylated in normal tissues and hypomethylated in 98% of human cancers. More recently, we provided evidence that hypomethylation of BAGE loci represents an informative marker for colon cancer detection. In this study, we show that hypomethylation of BAGE loci was an early event that occurred in 43% of colorectal adenomas. Interestingly, hypomethylation of BAGE loci was frequent (50%) in tubulo-villous and villous adenomas, these adenomas having a high probability of being transformed into colorectal cancers.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.