Asp Viper (Vipera aspis) Envenomation: Experience of the Marseille Poison Centre from 1996 to 2008

Toxins

Luc de Haro¹  Mathieu Glaizal²  Lucia Tichadou²  Ingrid Blanc-Brisset² 

[1] Centre Antipoison, hôpital Salvator, 249 boulevard Sainte Marguerite, 13009 Marseille, France;

关键词: asp viper;    snake envenomation;    antivenom;    neurotoxins;    Vipera genus;   

DOI  :  10.3390/toxins1020100

来源: mdpi

【 摘 要 】

A retrospective case review study of viper envenomations collected by the Marseille’s Poison Centre between 1996 and 2008 was performed. Results: 174 cases were studied (52 grade 1 = G1, 90 G2 and 32 G3). G1 patients received symptomatic treatments (average hospital stay 0.96 day). One hundred and six (106) of the G2/G3 patients were treated with the antivenom Viperfav* (2.1+/-0.9 days in hospital), while 15 of them received symptomatic treatments only (plus one immediate death) (8.1+/-4 days in hospital, 2 of them died). The hospital stay was significantly reduced in the antivenom treated group (p < 0.001), and none of the 106 antivenom treated patients had immediate (anaphylaxis) or delayed (serum sickness) allergic reactions. Conclusion: Viperfav* antivenom was safe and effective for treating asp viper venom-induced toxicity.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland