A History of Alcohol Dependence Increases the Incidence and Severity of Postoperative Cognitive Dysfunction in Cardiac Surgical Patients

International Journal of Environmental Research and Public Health

Judith A. Hudetz²  Kathleen M. Patterson¹  Alison J. Byrne¹  Zafar Iqbal²  Sweeta D. Gandhi²  David C. Warltier² 

[1] Clement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI 53295, USA; E-Mails:;Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA; E-Mails:

关键词: alcohol dependence;    cardiac surgery;    cardiopulmonary bypass;    neurocognitive function;   

DOI  :  10.3390/ijerph6112725

来源: mdpi

【 摘 要 】

Postoperative cognitive dysfunction (POCD) commonly occurs after cardiac surgery. We tested the hypothesis that a history of alcohol dependence is associated with an increased incidence and severity of POCD in male patients undergoing cardiac surgery using cardiopulmonary bypass. Recent verbal and nonverbal memory and executive functions were assessed before and one week after surgery in patients with or without a history of alcohol dependence. Cognitive function was significantly reduced after cardiac surgery in patients with versus without a history of alcohol dependence. The results suggest that a history of alcohol dependence increases the incidence and severity of POCD after cardiac surgery.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.