Liver Cell Transformation in Chronic HBV Infection

Viruses

Shirine Benhenda¹  Delphine Cougot¹  Christine Neuveut¹ 

[1] >Oncogenesis and Molecular Virology Unit, Institut Pasteur, Inserm U579, 28 rue duDr. Roux, 75724 Paris cedex 15, France; E-Mails: [e-mail] (S.B.); [e-mail] (D.C.); [e-mail] (C.N

关键词: hepatitis B virus;    hepatocellular carcinoma;    HBx;    pathogenesis;    transformation;   

DOI  :  10.3390/v1030630

来源: mdpi

【 摘 要 】

Epidemiological studies have provided overwhelming evidence for a causal role of chronic HBV infection in the development of hepatocellular carcinoma (HCC), but the molecular mechanisms underlying virally-induced tumorigenesis remain largely debated. In the absence of a dominant oncogene encoded by the HBV genome, indirect roles have been proposed, including insertional activation of cellular oncogenes by HBV DNA integration, induction of genetic instability by viral integration or by the regulatory protein HBx, and long term effects of viral proteins in enhancing immune-mediated liver disease. In this chapter, we discuss different models of HBV-mediated liver cell transformation based on animal systems of hepadnavirus infection as well as functional studies in hepatocyte and hepatoma cell lines. These studies might help identifying the cellular effectors connecting HBV infection and liver cell transformation.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland