Lyngbyastatins 8–10, Elastase Inhibitors with Cyclic Depsipeptide Scaffolds Isolated from the Marine Cyanobacterium Lyngbya semiplena

Marine Drugs

Jason C. Kwan²  Kanchan Taori²  Valerie J. Paul¹ 

[1] Smithsonian Marine Station, 701 Seaway Drive, Fort Pierce, FL 34949, USA; E-Mail:;Department of Medicinal Chemistry, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610; USA; E-Mails:

关键词: lyngbyastatins;    cyanobacteria;    Lyngbya semiplena;    cyclic depsipeptides;    elastase inhibitors;   

DOI  :  10.3390/md7040528

来源: mdpi

【 摘 要 】

Investigation of an extract from the marine cyanobacterium Lyngbya semiplena, collected in Tumon Bay, Guam, led to the identification of three new cyclodepsipeptides, lyngbyastatins 8–10 (1–3). The structures of 1–3 were determined by NMR, MS, ESIMS fragmentation and chemical degradation. Compounds 1–3 are closely related to lyngbyastatins 4–7. Like the latter compounds, we found 1–3 to inhibit porcine pancreatic elastase, with IC₅₀ values of 123 nM, 210 nM and 120 nM, respectively.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland