Examining the Dynamic Association of BMI and Mortality in the Framingham Heart Study

International Journal of Environmental Research and Public Health

Jianghua He¹  Daniel McGee²  Xufeng Niu² 

[1] Department of Biostatistics,University of Kansas Medical Center, Mail Stop 1026, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA;Department of Statistics, Florida State University,117 N. Woodward Ave. P.O. Box 3064330, Tallahassee, FL, 32306-4330, USA; E-Mails:

关键词: body mass index;    mortality;    time-varying association;    dynamic survival models;   

DOI  :  10.3390/ijerph6123115

来源: mdpi

【 摘 要 】

Based on the 40-year follow-up of the Framingham Heart Study (FHS), we used logistic regression models to demonstrate that different designs of an observational study may lead to different results about the association between BMI and all-cause mortality. We also used dynamic survival models to capture the time-varying relationships between BMI and mortality in FHS. The results consistently show that the association between BMI and mortality is dynamic, especially for men. Our analysis suggests that the dynamic property may explain part of the heterogeneity observed in the literature about the association of BMI and mortality.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.