Isolation and Chemical Characterization of a Toxin Isolated from the Venom of the Sea Snake, Hydrophis torquatus aagardi

Toxins

Masaya Nagamizu¹  Yumiko Komori¹  Kei-ichi Uchiya¹  Toshiaki Nikai¹ 

[1] Department of Microbiology, Faculty of Pharmacy, Meijo University, Nagoya 468-8503, Japan;

关键词: Hydrophiidae toxin;    Hydrophis torquatus aagardi toxin;    sea snake toxin;   

DOI  :  10.3390/toxins1020162

来源: mdpi

【 摘 要 】

Sea snakes (family: Hydrophiidae) are serpents found in the coastal areas of the Indian and Pacific Oceans. There are two subfamilies in Hydrophiidae: Hydrophiinae and Laticaudinae. A toxin, aagardi toxin, was isolated from the venom of the Hydrophiinae snake, Hydrophis torquatus aagardi and its chemical properties such as molecular weight, isoelectric point, importance of disulfide bonds, lack of enzymatic activity and amino acid sequence were determined. The amino acid sequence indicated a close relationship to the primary structure of other Hydrophiinae toxins and a significant difference from Laticaudinae toxins, confirming that primary toxin structure is closely related to sea snake phylogenecity.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland