Synthesis and Antimicrobial Activity of Some Pyridinium Salts

Molecules

Vildan Alptüzün¹  Sülünay Parlar¹  Hüseyin Taşlı¹ 

[1] ¹Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, 35100, Bornova, İzmir, Turkey ²Department of Microbiology, Faculty of Pharmacy, Ege University, 35100 Bornova, İzmir, Turkey

关键词: hydrazones;    pyridinium salts;    synthesis;    antimicrobial activity;   

DOI  :  10.3390/molecules14125203

来源: mdpi

【 摘 要 】

Some substituted benzylidenehydrazinylpyridinium derivatives bearing benzyl, ethylphenyl and propylphenyl groups on the pyridinium nitrogen were synthesized and screened for possible antibacterial and antifungal activities against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans using the microdilution method. Antimicrobial test results indicated that compounds containing a 3-phenylpropyl chain displayed the highest antimicrobial activity against Staphylococcus aureus and the compound 3d was the most active in the series against all tested bacteria and fungi strains.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.