The Effect of Long-Running Severe Selenium-Deficiency on the Amount of Iron and Zinc in the Organs of Rats

Molecules

Ken-ichiro Matsumoto¹  Sachiyo Terada¹  Marie Ariyoshi¹  Aya Okajo¹  Atsushi Hisamatsu¹  Iori Ui¹ 

[1] ¹Department of Physical Chemistry, Showa Pharmaceutical University, 3-3165 Higashi- Tamagawagakuen, Machida-shi, Tokyo 194-8543, Japan ²Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan

关键词: instrumental neutron activation analysis;    bio-trace element;    mineral;    aging;    oxidative stress;   

DOI  :  10.3390/molecules14114440

来源: mdpi

【 摘 要 】

The amounts of selenium (Se), iron (Fe), and zinc (Zn) in the liver, kidney, and spleen as a function of age of rats measured using instrumental neutron activation analysis were compared between Se-deficient (SeD) rats and normal rats. The SeD model rats can live for more than 50 weeks. The effect of Se-deficinecy in rats might be weak, compared to the marked malfunction of GSH-Px. The SeD rats can be considered as a model of nonlethal chronic oxidative stress. Fluctuations of Fe and Zn in the liver of Se-deficient rats were observed. The amount of redox-relating minerals, such as Fe and Zn, in SeD rat organs is changeable depending on the age.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.