The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights

Viruses

Stephen Hare¹ 

[1] >Division of Medicine, Imperial College London, St. Mary’s Campus, Norfolk Place, London, W2 1PG, UK; E-mail: [e-mail].

关键词: retrovirus;    integrase;    host factors;    protein-protein interaction;   

DOI  :  10.3390/v1030780

来源: mdpi

【 摘 要 】

Since its initial description as an HIV-1 integrase (IN) interactor seven years ago, LEDGF has become one of the best-characterized host factors involved in viral replication. Results of intensive studies in several laboratories indicated that the protein serves as a targeting factor for the lentiviral DNA integration machinery, and accounts for the characteristic preference of Lentivirus to integrate within active transcription units. The IN-LEDGF interaction has been put forward as a promising target for antiretroviral drug development and as a potential tool to improve safety of lentiviral vectors for use in gene therapy. Additionally, as a natural ligand of lentiviral IN proteins, LEDGF has been successfully used in structural biology studies of retroviral DNA integration. This review focuses on the structural aspects of the IN-LEDGF interaction and their functional consequences.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland