Viruses | |
The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights | |
Stephen Hare1  | |
[1] >Division of Medicine, Imperial College London, St. Mary’s Campus, Norfolk Place, London, W2 1PG, UK; E-mail: s.hare@imperial.ac. | |
关键词: retrovirus; integrase; host factors; protein-protein interaction; | |
DOI : 10.3390/v1030780 | |
来源: mdpi | |
【 摘 要 】
Since its initial description as an HIV-1 integrase (IN) interactor seven years ago, LEDGF has become one of the best-characterized host factors involved in viral replication. Results of intensive studies in several laboratories indicated that the protein serves as a targeting factor for the lentiviral DNA integration machinery, and accounts for the characteristic preference of
【 授权许可】
CC BY
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland
【 预 览 】
Files | Size | Format | View |
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RO202003190055580ZK.pdf | 453KB | download |