Hepatitis Delta Virus RNA Replication

Viruses

Chung-Hsin Tseng¹ 

[1] Institute of Molecular Biology, Academia Sinica, Nankang,Taipei 115, Taiwan

关键词: hepatitis delta virus;    hepatitis delta antigen;    RNA-dependent RNA synthesis;    RNA polymerases;    RNA replication;   

DOI  :  10.3390/v1030818

来源: mdpi

【 摘 要 】

Hepatitis delta virus (HDV) is a distant relative of plant viroids in the animal world. Similar to plant viroids, HDV replicates its circular RNA genome using a double rolling-circle mechanism. Nevertheless, the production of hepatitis delta antigen (HDAg), which is indispensible for HDV replication, is a unique feature distinct from plant viroids, which do not encode any protein. Here the HDV RNA replication cycle is reviewed, with emphasis on the function of HDAg in modulating RNA replication and the nature of the enzyme involved.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland