Chronic Stress and the Development of Early Atherosclerosis: Moderating Effect of Endothelial Dysfunction and Impaired Arterial Elasticity

International Journal of Environmental Research and Public Health

Nadja Chumaeva³  Mirka Hintsanen³  Niklas Ravaja²  Markus Juonala⁴  Olli T. Raitakari¹ 

[1]Department of Clinical Physiology, University of Turku, P.O. Box 52, 20521 Turku, Finland

[2] E-Mail:

[3]Center for Knowledge and Innovation Research, Helsinki School of Economics, P.O. Box 1210, 00101 Helsinki, Finland

[4] E-Mail:

[5]Department of Psychology, University of Helsinki, P.O. Box 9, 00014 Helsinki, Finland

[6] E-Mails:

[7]Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinanmyllynkatu 10, 20520 Turku, Finland

[8] E-Mails:

关键词: chronic stress;    vital exhaustion;    intima-media thickness;    flow-mediated dilatation;    carotid artery compliance;    atherosclerosis;   

DOI  :  10.3390/ijerph6122934

来源: mdpi

【 摘 要 】

This study aims to explore the interactive effect of vital exhaustion (VE) and endothelial dysfunction on preclinical atherosclerosis, assessed by carotid intima-media thickness (IMT). Furthermore, interaction between VE and carotid elasticity is examined. Participants were 1,596 young healthy adults from the Cardiovascular Risk in Young Finns study. Endothelial dysfunction was measured by brachial flow-mediated dilatation (FMD), and carotid elasticity by carotid artery compliance (CAC). Significant interactions between FMD and VE, and between CAC and VE, for IMT were found in participants with the very lowest FMD and CAC. Thus, VE may be harmful if the endothelium is not working properly.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.