Marine Drugs | |
Marine Pyrrolocarbazoles and Analogues: Synthesis and Kinase Inhibition | |
Sstien Deslandes1  Stefan Chassaing1  | |
[1] Laboratoire de Synthèse et Physicochimie de Molécules d’Intérêt Biologique, UMR CNRS 5068, Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cédex 9, France; | |
关键词: granulatimide; isogranulatimide; pyrrolocarbazole; indolocarbazole; kinase inhibitor; | |
DOI : 10.3390/md7040754 | |
来源: mdpi | |
【 摘 要 】
Granulatimide and isogranulatimide are alkaloids obtained from marine sources which have been shown to inhibit cell-cycle G2-checkpoint, targeting more particularly checkpoint 1 kinase (Chk1). At a structural level, they possess a characteristic pyrrolocarbazole framework also shared by the well-known rebeccamycin and staurosporine microbial metabolites which have been described to inhibit topoisomerase I and diverse kinases, respectively. This review reports precisely on the synthesis and kinase inhibitory activities of pyrrolocarbazole-based analogues of granulatimide.
【 授权许可】
CC BY
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland
【 预 览 】
Files | Size | Format | View |
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RO202003190055364ZK.pdf | 955KB | download |