Marine Pyrrolocarbazoles and Analogues: Synthesis and Kinase Inhibition

Marine Drugs

Sstien Deslandes¹  Stefan Chassaing¹ 

[1] Laboratoire de Synthèse et Physicochimie de Molécules d’Intérêt Biologique, UMR CNRS 5068, Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cédex 9, France;

关键词: granulatimide;    isogranulatimide;    pyrrolocarbazole;    indolocarbazole;    kinase inhibitor;   

DOI  :  10.3390/md7040754

来源: mdpi

【 摘 要 】

Granulatimide and isogranulatimide are alkaloids obtained from marine sources which have been shown to inhibit cell-cycle G2-checkpoint, targeting more particularly checkpoint 1 kinase (Chk1). At a structural level, they possess a characteristic pyrrolocarbazole framework also shared by the well-known rebeccamycin and staurosporine microbial metabolites which have been described to inhibit topoisomerase I and diverse kinases, respectively. This review reports precisely on the synthesis and kinase inhibitory activities of pyrrolocarbazole-based analogues of granulatimide.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland