Pandemic Influenza Vaccines – The Challenges

Viruses

Lars R. Haaheim¹  Abdullah S. Madhun² 

[1] Myrdalskogen 95, N-5117 Ulset, Norway;Influenza Centre, The Gade Institute, University of Bergen, Laboratory Building, 5th Floor,Haukeland University Hospital, N-5021 Bergen, Norway; E-Mails: [e-mail] (A.S.M.); [e-mail] (R.C.)

关键词: influenza;    H5N1;    H1N1;    pandemic;    vaccine;    haemagglutinin (HA);    neuraminidase (NA);   

DOI  :  10.3390/v1031089

来源: mdpi

【 摘 要 】

Recent years’ enzootic spread of highly pathogenic H5N1 virus among poultry and the many lethal zoonoses in its wake has stimulated basic and applied pandemic vaccine research. The quest for an efficacious, affordable and timely accessible pandemic vaccine has been high on the agenda. When a variant H1N1 strain of swine origin emerged as a pandemic virus, it surprised many, as this subtype is well-known to man as a seasonal virus. This review will cover some difficult vaccine questions, such as the immunological challenges, the new production platforms, and the limited supply and global equity issues.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland