Clostridium perfringens Iota-Toxin: Structure and Function

Toxins

Jun Sakurai²  Masahiro Nagahama²  Masataka Oda²  Hideaki Tsuge¹ 

[1] Institute for Health Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan;Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan

关键词: Clostridium perfringens;    iota-toxin;    ADP-ribosylating toxin;    NAD⁺-glycohydrolase;    ADP-ribosyltransferase;    crystal structure;    SN1 mechanism;    internalization;    endocytosis;   

DOI  :  10.3390/toxins1020208

来源: mdpi

【 摘 要 】

Clostridium perfringens iota-toxin is composed of the enzyme component (Ia) and the binding component (Ib). Ib binds to receptor on targeted cells and translocates Ia into the cytosol of the cells. Ia ADP-ribosylates actin, resulting in cell rounding and death. Comparisons of the deduced amino acid sequence from the gene and three-dimensional structure of Ia with those of ADP-ribosylating toxins (ARTs) suggests that there is striking structural similarity among these toxins. Our objectives are to review the recent advances in the character, structure-function, and the mode of action of iota-toxin by consideration of the findings about ARTs.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland