Transition-Metal-Free Highly Efficient Aerobic Oxidation of Sulfides to Sulfoxides under Mild Conditions

Molecules

Hua Zhang¹  Chunyu Chen¹  Renhua Liu¹  Qiang Xu¹ 

[1] ¹State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, No.158-139, Zhongshan Road, Dalian 116012, China ²School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

关键词: aerobic oxidation;    sulfids;    Br2;    NaNO2;    molecular oxygen;   

DOI  :  10.3390/molecules15010083

来源: mdpi

【 摘 要 】

A highly efficient transition-metal-free catalytic system Br₂/NaNO₂/H₂O has been developed for a robust and economic acid-free aerobic oxidation of sulfides. It is noteworthy that the sulfide function reacts under mild conditions without over-oxidation to sulfone. The role of NaNO₂as an efficient NO equivalent for the activation of molecular oxygen was identified. Under the optimal conditions, a broad range of sulfide substrates were converted into their corresponding sulfoxides in high yields by molecular oxygen. The present catalytic system utilizes cheap and readily available agents as the catalysts, exhibits high selectivity for sulfoxide products and releases only innocuous water as the by-products.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.