PEGylated Adenoviruses: From Mice to Monkeys

Viruses

Piyanuch Wonganan¹ 

[1] Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA; E-Mail: [e-mail]

关键词: adenovirus;    gene therapy;    vaccine;    toxicity;    PEGylation;    targeting;    pharmacokinetics;    immune response;    tolerance;    non-viral vectors;   

DOI  :  10.3390/v2020468

来源: mdpi

【 摘 要 】

Covalent modification with polyethylene glycol (PEG), a non-toxic polymer used in food, cosmetic and pharmaceutical preparations for over 60 years, can profoundly influence the pharmacokinetic, pharmacologic and toxciologic profile of protein and peptide-based therapeutics. This review summarizes the history of PEGylation and PEG chemistry and highlights the value of this technology in the context of the design and development of recombinant viruses for gene transfer, vaccination and diagnostic purposes. Specific emphasis is placed on the application of this technology to the adenovirus, the most potent viral vector with the most highly characterized toxicity profile to date, in several animal models.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland