Developing Vaccines to Combat Pandemic Influenza

Viruses

James S. Robertson¹ 

关键词: pandemic influenza vaccines;    reverse genetics;    H5N1 virus;    H1N1v virus;   

DOI  :  10.3390/v2020532

来源: mdpi

【 摘 要 】

Influenza vaccine manufacturers require antigenically relevant vaccine viruses that have good manufacturing properties and are safe to use. In developing pandemic vaccine viruses, reverse genetics has been employed as a rational approach that can also be used effectively to attenuate the highly virulent H5N1 virus and at the same time place the H5 HA and N1 NA on a background of PR8, a virus that has been used over many decades to provide high yielding vaccine viruses. Reverse genetics has also been used successfully alongside classical reassorting techniques in the development of (swine flu) pandemic A(H1N1)v vaccine viruses.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland