ESI FTICR-MS Analysis of Larvae from the Marine Sponge Luffariella variabilis

Marine Drugs

Cherie A. Motti¹  Piers Ettinger-Epstein²  Richard H. Willis¹ 

[1] Australian Institute of Marine Science, Townsville, Queensland, 4810, Australia; E-Mails:;AIMS@JCU, Sir George Fisher Building, James Cook University, Townsville, 4811, Queensland, Australia; E-Mail:

关键词: Luffariella variabilis;    manoalide monoacetate;    larvae;    ESI FTICR-MS;    constitutive defence;   

DOI  :  10.3390/md8010190

来源: mdpi

【 摘 要 】

The viviparous Great Barrier Reef sponge Luffariella variabilis (Poléjaeff 1884) contains a range of secondary metabolites, including manoalide (1) and manoalide monoacetate (3). ESI (+) FTICR-MS accurate mass determination has, for the first time, been used to detected the presence of 3 only in an organic extract of a single L. variabilis larva showing that the parentally produced 3 is sequestered in the larva. As 3 has previously been shown to have antibacterial and quorum sensing inhibition activity, and readily converts to 1, which also exhibits similar activity, it may provide a chemical defence against predation and microbial attack.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland