International Journal of Molecular Sciences | |
QSAR Studies on Andrographolide Derivatives as α-Glucosidase Inhibitors | |
Jun Xu2  Sichao Huang2  Haibin Luo1  Guoji Li2  Jiaolin Bao2  Shaohui Cai2  | |
[1] School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510275, China; E-Mail:;Pharmacy College, Jinan University, Guangzhou, 510632, China; E-Mails: | |
关键词: andrographolide; QSAR; α-glucosidase; HQSAR; | |
DOI : 10.3390/ijms11030880 | |
来源: mdpi | |
【 摘 要 】
Andrographolide derivatives were shown to inhibit α-glucosidase. To investigate the relationship between activities and structures of andrographolide derivatives, a training set was chosen from 25 andrographolide derivatives by the principal component analysis (PCA) method, and a quantitative structure-activity relationship (QSAR) was established by 2D and 3D QSAR methods. The cross-validation
【 授权许可】
CC BY
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
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