The Influence of α-, β-, and γ-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice

Molecules

Vladimir Blagaić¹  Karlo Houra¹  Petra Turčić¹  Nikola Štambuk¹  Paško Konjevoda¹  Alenka Boban-Blagaić¹  Tomislav Kelava¹  Marina Kos¹  Gorana Aralica¹ 

[1]¹University Hospital “Sveti Duh”, Sveti Duh 64, 10000 Zagreb, Croatia

关键词: melanocortins;    alpha-MSH;    beta-MSH;    gamma-MSH;    acetaminophen;    liver;   

DOI  :  10.3390/molecules15031232

来源: mdpi

【 摘 要 】

Research over the past decade has indicated that melanocortin peptides are potent inhibitors of inflammation and a promising source of new anti-inflammatory and cytoprotective therapies. The purpose of the present paper is to compare protective effects of α-, β-, and γ-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice. Acetaminophen was applied intragastrically in a dose of 150 mg/kg, and tested substances were applied intraperitoneally 1 hour before acetaminophen. Mice were sacrificed after 24 hours and intensity of liver injury was estimated by measurement of plasma transaminase activity (AST and ALT) and histopathological grading of lesions. It was found that α-, β-, and γ-MSH decrease intensity of lesions by both criteria in a dose-dependent manner.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.