Cell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the Brain

Pharmaceuticals

Xanthi Antoniou¹ 

[1] Istituto di Ricerche Farmacologiche "Mario Negri", Via La Masa 19, 20157 Milano, Italy; E-Mail

关键词: CPPs;    neuroprotection;    protein-protein interaction;    drug discovery;    brain;   

DOI  :  10.3390/ph3020379

来源: mdpi

【 摘 要 】

The inability of most drugs to cross the blood-brain barrier and/or plasma membrane limits their use for biomedical applications in the brain. Cell Permeable Peptides (CPPs) overcome this problem and are effective in vivo, crossing the plasma membrane and the blood-brain barrier. CPPs deliver a wide variety of compounds intracellularly in an active form. In fact, many bioactive cargoes have neuroprotective properties, and due to their ability to block protein-protein interactions, offer exciting perspectives in the clinical setting. In this review we give an overview of the Cell Permeable Peptides strategy to deliver neuroprotectants against neurodegeneration in the CNS.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.