Novel Neuroprotective Strategies in Ischemic Retinal Lesions

International Journal of Molecular Sciences

Krisztina Szabadfi³  Laszlo Mester²  Dora Reglodi¹  Peter Kiss¹  Norbert Babai³  Boglarka Racz²  Krisztina Kovacs²  Aliz Szabo²  Andrea Tamas¹  Robert Gabriel³ 

[1] Department of Anatomy, University of Pecs, H-7624 Pecs, Hungary; E-Mails:;Department of Biochemistry and Medical Chemistry, University of Pecs, H-7624 Pecs, Hungary; E-Mails:;Department of Experimental Zoology and Neurobiology, University of Pecs, H-7624 Pecs, Hungary; E-Mails:

关键词: BCCAO;    ischemia;    retinoprotection;    urocortin 2;    diazoxide;    PACAP;    PARP-inhibitor;    rat retina;   

DOI  :  10.3390/ijms11020544

来源: mdpi

【 摘 要 】

Retinal ischemia can be effectively modeled by permanent bilateral common carotid artery occlusion, which leads to chronic hypoperfusion-induced degeneration in the entire rat retina. The complex pathways leading to retinal cell death offer a complex approach of neuroprotective strategies. In the present review we summarize recent findings with different neuroprotective candidate molecules. We describe the protective effects of intravitreal treatment with: (i) urocortin 2; (ii) a mitochondrial ATP-sensitive K⁺ channel opener, diazoxide; (iii) a neurotrophic factor, pituitary adenylate cyclase activating polypeptide; and (iv) a novel poly(ADP-ribose) polymerase inhibitor (HO3089). The retinoprotective effects are demonstrated with morphological description and effects on apoptotic pathways using molecular biological techniques.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.