Microwave-Assisted and Efficient Solvent-free Knoevenagel Condensation. A Sustainable Protocol Using Porous Calcium Hydroxyapatite as Catalyst

Molecules

Siham Mallouk¹  Khalid Bougrin¹  Abdelaziz Laghzizil¹ 

[1] ¹Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, Université Mohammed V-Agdal, Faculté des Sciences, B.P. 1014 R.P, Rabat, Maroc

关键词: solvent-free;    sustainable procedure;    microwave;    Knoevenagel;    catalysis;   

DOI  :  10.3390/molecules15020813

来源: mdpi

【 摘 要 】

A sustainable Knoevenagel condensation of a series of aldehydes with malononitrile and ethyl cyanoacetate is described. The process is based on the combination of microwave activation and hydroxyapatite catalysis under solvent-free conditions. Products are obtained in and high yields after short reaction times. The effects of the specific surface of porous calcium hydroxyapatite and microwave activation are discussed.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.