Dietary Phospholipids and Intestinal Cholesterol Absorption

Nutrients

Jeffrey S. Cohn¹  Alvin Kamili²  Elaine Wat²  Rosanna W. S. Chung² 

[1] Nutrition and Metabolism Group, Heart Research Institute, 7 Eliza St. Newtown 2042 NSW, Sydney, Australia;

关键词: cardiovascular disease;    cholesterol;    intestine;    micelle;    phosphatidylcholine;    phosphatidylethanolamine;    phospholipid;    sphingomyelin;   

DOI  :  10.3390/nu2020116

来源: mdpi

【 摘 要 】

Experiments carried out with cultured cells and in experimental animals have consistently shown that phospholipids (PLs) can inhibit intestinal cholesterol absorption. Limited evidence from clinical studies suggests that dietary PL supplementation has a similar effect in man. A number of biological mechanisms have been proposed in order to explain how PL in the gut lumen is able to affect cholesterol uptake by the gut mucosa. Further research is however required to establish whether the ability of PLs to inhibit cholesterol absorption is of therapeutic benefit.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.