3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington’s Disease: Past, Present and Future

Molecules

Isaac Túnez¹  Inmaculada Tasset¹  Verónica Pérez-De La Cruz¹ 

[1] ¹Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Maimónides de Investigaciones Biomédicas de Córdoba (IMIBIC), Universidad de Córdoba, Av. Menéndez Pidal s/n, 14004 Córdoba, Spain ²Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía “Manuel Velasco Suárez”, México D.F., Mexico

关键词: 3-nitropropionic acid;    Huntington’s disease;    quinolinic acid;    succinate dehydrogenase;    transgenic mice models;   

DOI  :  10.3390/molecules15020878

来源: mdpi

【 摘 要 】

Huntington’s disease (HD) is an inheritable autosomal-dominant disorder whose causal mechanisms remain unknown. Experimental models have begun to uncover these pathways, thus helping to understand the mechanisms implicated and allowing for the characterization of potential targets for new therapeutic strategies. 3-Nitropropionic acid is known to produce in animals behavioural, biochemical and morphologic changes similar to those occurring in HD. For this reason, this phenotypic model is gaining attention as a valuable tool to mimick this disorder and further developing new therapies. In this review, we will focus on the past and present research of this molecule, to finally bring a perspective on what will be next in this promising field of study.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.