Tissue Response to, and Degradation Rate of, Photocrosslinked Trimethylene Carbonate-Based Elastomers Following Intramuscular Implantation

Materials

Laurianne Timbart¹  Man Yat Tse²  Stephen C. Pang² 

[1] Department of Chemical Engineering, Dupuis Hall, Queen’s University, Kingston, Ontario K7L 3N6, Canada; E-Mail:;Department of Anatomy and Cell Biology, Botterell Hall, Queen's University, Kingston, Ontario K7L 3N6, Canada; E-Mails:

关键词: in vivo;    trimethylene carbonate;    elastomer;    lactide;    caprolactone;    tissue response;    mechanical properties;   

DOI  :  10.3390/ma3021156

来源: mdpi

【 摘 要 】

Cylindrical elastomers were prepared through the UV-initiated crosslinking of terminally acrylated, 8,000 Da star-poly(trimethylene carbonate-co-ε-caprolactone) and star-poly(trimethylene carbonate-co-D,L-lactide). These elastomers were implanted intramuscularly into the hind legs of male Wistar rats to determine the influence of the comonomer on the weight loss, tissue response, and change in mechanical properties of the elastomer. The elastomers exhibited only a mild inflammatory response that subsided after the first week; the response was greater for the stiffer D,L-lactide-containing elastomers. The elastomers exhibited weight loss and sol content changes consistent with a bulk degradation mechanism. The D,L-lactide-containing elastomers displayed a nearly zero-order change in Young’s modulus and stress at break over the 30 week degradation time, while the ε-caprolactone-containing elastomers exhibited little change in modulus or stress at break.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.