Marine Drugs | |
Regulation of the Spontaneous Augmentation of NaV1.9 in Mouse Dorsal Root Ganglion Neurons: Effect of PKA and PKC Pathways | |
Jun-ichi Kakimura2  Taixing Zheng1  Noriko Uryu1  | |
[1] Department of Neurophysiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, 734-8551, Japan; E-Mails:;Technical Center, Hiroshima University, Hiroshima, 734-8551, Japan | |
关键词: Na+ channel; tetrodotoxin; dorsal root ganglion; patch clamp; PKA; PKC; | |
DOI : 10.3390/md8030728 | |
来源: mdpi | |
【 摘 要 】
Sensory neurons in the dorsal root ganglion express two kinds of tetrodotoxin resistant (TTX-R) isoforms of voltage-gated sodium channels, NaV1.8 and NaV1.9. These isoforms play key roles in the pathophysiology of chronic pain. Of special interest is NaV1.9: our previous studies revealed a unique property of the NaV1.9 current,
【 授权许可】
CC BY
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland
【 预 览 】
Files | Size | Format | View |
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RO202003190054523ZK.pdf | 230KB | download |