The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD+(H)

Nutrients

John Mach³  Adrian W. Midgley¹  Steve Dank²  Ross S. Grant³ 

[1] Department of Sport, Health and Exercise Science, University of Hull, Hull, HU6 7RX, UK;Department of Pharmacology, University of Sydney, Sydney, 2006, Australia;School of Medical Science, University of New South Wales, Kensington, 2052, Australia;

关键词: NAD⁺;    NADH;    exercise;    oxidative stress;    antioxidant;   

DOI  :  10.3390/nu2030319

来源: mdpi

【 摘 要 】

This study compared serum pyridine levels (NAD⁺ /NADH) in trained (n = 6) and untrained (n = 7) subjects after continuous progressive exercise at 50%, 70% then 95% of physical work capacity until fatigue (TTF) after consuming a placebo or antioxidant (AO) cocktail (Lactaway^©). An increase of 17% in TTF was observed in AO as compared to placebo (p = 0.032). This was accompanied by a significant increase in serum NAD⁺ levels (p = 0.037) in the AO supplemented group post exercise. The increases in NAD⁺ and improved endurance reflect lower oxidative stress-induced suppression of aerobic respiration.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.