Inhibition of Hemorragic Snake Venom Components: Old and New Approaches

Toxins

Isabella Panfoli¹  Daniela Calzia²  Silvia Ravera² 

[1] Department of Biology, University of Genova, Viale Benedetto XV 3, 16132 Genova, Italy;

关键词: antivenins;    direct electric current;    etnomedicine;    metalloprotease;    phospholipase A2;    phosphodiesterase;    snake venom;   

DOI  :  10.3390/toxins2040417

来源: mdpi

【 摘 要 】

Snake venoms are complex toxin mixtures. Viperidae and Crotalidae venoms, which are hemotoxic, are responsible for most of the envenomations around the world. Administration of antivenins aimed at the neutralization of toxins in humans is prone to potential risks. Neutralization of snake venom toxins has been achieved through different approaches: plant extracts have been utilized in etnomedicine. Direct electric current from low voltage showed neutralizing properties against venom phospholipase A2 and metalloproteases. This mini-review summarizes new achievements in venom key component inhibition. A deeper knowledge of alternative ways to inhibit venom toxins may provide supplemental treatments to serum therapy.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland