Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles

Molecules

Hussein El-Kashef¹  Abdel-Rahman Farghaly¹  Ahmed Al-Hazmi¹  Thierry Terme¹ 

[1] ¹Chemistry Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt ²Chemistry Department, Faculty of Science, Ibb University, Yemen ³Laboratoire Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Universités d’Aix-Marseille I, II et III-CNRS, UMR 6264, Laboratoire Chimie Provence, 27 Bd J. Moulin, 13385 Marseille cedex 5, France

关键词: pyrimidines;    pyridines;    thienopyrimidines;    fused pyrimidines;    fused pyridines;   

DOI  :  10.3390/molecules15042651

来源: mdpi

【 摘 要 】

The synthesis of the title compounds was achieved using ethyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (1) as starting material. The reaction of the amino ester 1 with phenylisothiocyanate in boiling ethanol afforded the thiourea derivative 5. The cyclization reactions of 5 under different reaction conditions led to different pyridothienopyrimidine derivatives. Other reactions of the latter derivatives leading to pyrido[4',3':4,5]thieno[2,3-d]triazolo[1,5-a]pyrimidines are also presented.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.