Chemical Constituents of Excoecaria acerifolia and Their Bioactivities

Molecules

Yan-Li Zhao¹  Qiu-Xia He¹  Yang Li¹  Si-Feng Wang¹  Ke-Chun Liu¹  Yong-Ping Yang¹ 

[1] ¹¨Laboratory of Ethnobotany, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China

关键词: kaurane diterpenoid;    Excoecaria acerifolia;    NMR;    antiangiogenic;    antiproliferative;   

DOI  :  10.3390/molecules15042178

来源: mdpi

【 摘 要 】

A new kaurane diterpenoid, 3α,18-dihydroxy-3β,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.