Towards a Guided Regeneration of Renal Tubules at a Polyester Interstitium

Materials

Will W. Minuth¹  Lucia Denk² 

[1] Department of Molecular and Cellular Anatomy, University of Regensburg, University Street 31, 93053 Regensburg, Germany;

关键词: polyester fleece;    artificial interstitium;    kidney;    stem/progenitor cells;    regeneration;    aldosterone;   

DOI  :  10.3390/ma3042369

来源: mdpi

【 摘 要 】

Stem/progenitor cells are promising candidates for a therapy of renal failure. However, sound knowledge about implantation and regeneration is lacking. Therefore, mechanisms leading from stem/progenitor cells into tubules are under research. Renal stem/progenitor cells were isolated from neonatal rabbit kidney and mounted between layers of polyester fleece. It creates an artificial interstitium and replaces coating by extracellular matrix proteins. Tubulogenic development is induced by aldosterone. Electron microscopy illuminates growth of tubules in close vicinity to polyester fibers. Tubules contain a differentiated epithelium. The spatial extension of tubules opens a new strategy for testing morphogenic drugs and biocompatible fleece materials.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.