Effects of Aflatoxin B1 and Fumonisin B1 on Blood Biochemical Parameters in Broilers

Toxins

Eliana N. C. Tessari³  Estela Kobashigawa¹  Ana Lྫྷia S. P. Cardoso³  David R. Ledoux⁴  George E. Rottinghaus² 

[1] Department of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil;Veterinary Medical Diagnostic Laboratory, College Veterinary Medicine, University of Missouri, Columbia, Missouri, USA;Center for Advanced Technological Research on Poultry, Biological Institute, Descalvado, SP, Brazil;Department of Animal Science, University of Missouri, Columbia, Missouri, USA;

关键词: AFB₁;    FB₁;    broiler chickens;    toxic effects;   

DOI  :  10.3390/toxins2040453

来源: mdpi

【 摘 要 】

The individual and combined effects of dietary aflatoxin B₁ (AFB₁) and fumonisin B₁ (FB₁) on liver pathology, serum levels of aspartate amino-transferase (AST) and plasma total protein (TP) of broilers were evaluated from 8 to 41 days of age. Dietary treatments included a 3 × 3 factorial arrangement with three levels of AFB₁ (0, 50 and 200 μg AFB₁/kg), and three levels of FB₁ (0, 50 and 200 mg FB₁/kg). At 33 days post feeding, with the exception of birds fed 50 mg FB₁ only, concentrations of AST were higher (p < 0.05) in all other treatment groups when compared with controls. Plasma TP was lower (p < 0.05) at six days post feeding in groups fed 200 μg AFB₁/kg alone or in combination with FB₁. At day 33 days post feeding, with the exception of birds fed the highest combination of AFB₁ and FB₁ which had higher plasma TP than control birds_, plasma TP of birds fed other dietary treatments were similar to controls. Broilers receiving the highest levels of AFB₁ and FB₁ had bile duct proliferation and trabecular disorder in liver samples. AFB₁ singly or in combination with FB at the levels studied, caused liver damage and an increase in serum levels of AST.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland