期刊论文详细信息
Toxins
Effects of Aflatoxin B1 and Fumonisin B1 on Blood Biochemical Parameters in Broilers
Eliana N. C. Tessari3  Estela Kobashigawa1  Ana Lྫྷia S. P. Cardoso3  David R. Ledoux4  George E. Rottinghaus2 
[1] Department of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil;Veterinary Medical Diagnostic Laboratory, College Veterinary Medicine, University of Missouri, Columbia, Missouri, USA;Center for Advanced Technological Research on Poultry, Biological Institute, Descalvado, SP, Brazil;Department of Animal Science, University of Missouri, Columbia, Missouri, USA;
关键词: AFB1;    FB1;    broiler chickens;    toxic effects;   
DOI  :  10.3390/toxins2040453
来源: mdpi
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【 摘 要 】

The individual and combined effects of dietary aflatoxin B1 (AFB1) and fumonisin B1 (FB1) on liver pathology, serum levels of aspartate amino-transferase (AST) and plasma total protein (TP) of broilers were evaluated from 8 to 41 days of age. Dietary treatments included a 3 × 3 factorial arrangement with three levels of AFB1 (0, 50 and 200 μg AFB1/kg), and three levels of FB1 (0, 50 and 200 mg FB1/kg). At 33 days post feeding, with the exception of birds fed 50 mg FB1 only, concentrations of AST were higher (p < 0.05) in all other treatment groups when compared with controls. Plasma TP was lower (p < 0.05) at six days post feeding in groups fed 200 μg AFB1/kg alone or in combination with FB1. At day 33 days post feeding, with the exception of birds fed the highest combination of AFB1 and FB1 which had higher plasma TP than control birds, plasma TP of birds fed other dietary treatments were similar to controls. Broilers receiving the highest levels of AFB1 and FB1 had bile duct proliferation and trabecular disorder in liver samples. AFB1 singly or in combination with FB at the levels studied, caused liver damage and an increase in serum levels of AST.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland

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