Novel Indole-Based Analogs of Melatonin: Synthesis and in Vitro Antioxidant Activity Studies

Molecules

Hanif Shirinzadeh¹  Burcu Eren¹  Hande Gurer-Orhan¹  Sibel Suzen¹ 

[1] ¹Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey ²Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, 35100 Bornova, Izmir, Turkey

关键词: indole;    hydrazone;    hydrazide;    melatonin;    synthesis;    antioxidant activity;   

DOI  :  10.3390/molecules15042187

来源: mdpi

【 摘 要 】

The aim of this study was to synthesize and examine possible in vitro antioxidant effects of indole-based melatonin analogue compounds. As a part of our ongoing study nineteen indole hydrazide/hydrazone derivatives were synthesized, characterized and their in vitro antioxidant activity was investigated by three different assays: by evaluating their reducing effect against oxidation of a redox sensitive fluorescent probe, by examining their protective effect against H₂O₂-induced membrane lipid peroxidation and by determining their inhibitory effect on AAPH–induced hemolysis of human erythrocytes. The results indicated significant strong antioxidant activity for most of the compounds, when compared to melatonin.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.