In Vivo Study of the Effects of Peptide-Conjugated Near-Infrared Fluorescent Quantum Dots on the Tumorigenic and Lymphatic Metastatic Capacities of Squamous Cell Carcinoma Cell Line Tca8113 and U14

International Journal of Molecular Sciences

Zhi-Gang Li²  Kai Yang²  Yu-An Cao²  Gang Zheng¹  De-Ping Sun²  Cheng Zhao² 

[1] Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400013, China;Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China

关键词: peptide;    near-infrared fluorescence;    quantum dots;    tumor;    growth;    proliferation;    apoptosis;    metastasis;   

DOI  :  10.3390/ijms11041413

来源: mdpi

【 摘 要 】

Quantum dots (QDs) have great potential in non-invasive monitoring and imaging of tumor cells in vivo, but it is unknown if QDs affect their tumorigenesis and metastasis. Here, we applied peptide-conjugated near-infrared fluorescent QDs (NIRF-QDs) to label the squamous cell carcinoma cells Tca8113 and U14. We tested the proliferation and apoptotic capacities of both cells, and the capacity of cervical lymph node metastasis after tumorigenesis in U14 cells’. We find that QDs do not affect the tumor cells’ capacities to grow, proliferate, and metastasize. Our study provides critical data to support the application of NIRF-QDs in non-invasive monitoring and imaging of tumor cells in vivo.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.