Anticancer Effect and Structure-Activity Analysis of Marine Products Isolated from Metabolites of Mangrove Fungi in the South China Sea

Marine Drugs

Li-yang Tao²  Jian-ye Zhang²  Yong-ju Liang²  Li-ming Chen²  Li-sheng Zhen²  Fang Wang²  Yan-jun Mi²  Zhi-gang She¹  Kenneth Kin Wah To³  Yong-cheng Lin¹ 

[1] School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, 510275, China;State Key Laboratory for Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, 510060, China; E-Mails:;School of Pharmacy, The Chinese University of Hong Kong, Hong Kong, China; E-Mail:

关键词: mangrove fungi;    multidrug resistance (MDR);    quinones;    xyloketal;    isoflavone;    prostaglandins;   

DOI  :  10.3390/md8041094

来源: mdpi

【 摘 要 】

Marine-derived fungi provide plenty of structurally unique and biologically active secondary metabolites. We screened 87 marine products from mangrove fungi in the South China Sea for anticancer activity by MTT assay. 14% of the compounds (11/86) exhibited a potent activity against cancer in vitro. Importantly, some compounds such as compounds 78 and 81 appeared to be promising for treating cancer patients with multidrug resistance, which should encourage more efforts to isolate promising candidates for further development as clinically useful chemotherapeutic drugs. Furthermore, DNA intercalation was not involved in their anticancer activities, as determined by DNA binding assay. On the other hand, the structure-activity analysis indicated that the hydroxyl group was important for their cytotoxic activity and that bulky functional groups such as phenyl rings could result in a loss of biological activity, which will direct the further development of marine product-based derivatives.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland