Molecules | |
Pellitorine, a Potential Anti-Cancer Lead Compound against HL60 and MCT-7 Cell Lines and Microbial Transformation of Piperine from Piper Nigrum | |
Gwendoline Cheng Lian Ee1  Chyi Meei Lim1  Mawardi Rahmani1  Khozirah Shaari1  | |
[1] 1Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia 2Department of Crop Science, Faculty of Agriculture & Food Sciences, Universiti Putra Malaysia Bintulu Campus, 97008, Bintulu, Sarawak, Malaysia | |
关键词: Piper nigrum; pellitorine; alkaloids; cytotoxicity; microbial transformation; aspergillus niger; | |
DOI : 10.3390/molecules15042398 | |
来源: mdpi | |
【 摘 要 】
Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Piper nigrum. They are (E)-1-[3’,4’-(methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). These compounds were isolated using chromatographic methods and their structures were elucidated using MS, IR and NMR techniques.
【 授权许可】
CC BY
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
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