Pellitorine, a Potential Anti-Cancer Lead Compound against HL60 and MCT-7 Cell Lines and Microbial Transformation of Piperine from Piper Nigrum

Molecules

Gwendoline Cheng Lian Ee¹  Chyi Meei Lim¹  Mawardi Rahmani¹  Khozirah Shaari¹ 

[1] ¹Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia ²Department of Crop Science, Faculty of Agriculture & Food Sciences, Universiti Putra Malaysia Bintulu Campus, 97008, Bintulu, Sarawak, Malaysia

关键词: Piper nigrum;    pellitorine;    alkaloids;    cytotoxicity;    microbial transformation;    aspergillus niger;   

DOI  :  10.3390/molecules15042398

来源: mdpi

【 摘 要 】

Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Piper nigrum. They are (E)-1-[3’,4’-(methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). These compounds were isolated using chromatographic methods and their structures were elucidated using MS, IR and NMR techniques.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.