Essential Oil of Myrtus communis L. as a Potential Antioxidant and Antimutagenic Agents

Molecules

Neda Mimica-Dukić¹  Dušan Bugarin¹  Slavenko Grbović¹  Dragana Mitić-Ćulafić¹  Branka Vuković-Gačić¹  Dejan Orčić¹  Emilija Jovin¹ 

[1]¹Department of Chemistry, Biochemistry and Environmental Protection, University of Novi Sad Faculty of Sciences. Trg Dositeja Obradovica 3. 21 000 Novi Sad, Serbia

关键词: Myrtus communis L.;    essential oil;    a-pinene;    1;    8-cineole;    myrtenyl acetate;    mutagenesis;    DPPH test;   

DOI  :  10.3390/molecules15042759

来源: mdpi

【 摘 要 】

The present study describes DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity and antimutagenic properties of the essential oil of myrtle (Myrtus communis L.). Plant samples were collected from the two distant localities (southernmost and northern point) of the Montenegro coastline. Chemical profiles of the two samples were evaluated by GC-MS. In both of the samples monoterpenes were found to be the predominant compounds. Among them a-pinene, linalool, 1,8-cineole, and myrtenyl acetate were the major compounds. Significant differences between the samples were found in the ranges of a-pinene (14.7%–35.9%) and myrtenyl acetate (5.4%–21.6%). Both oils exhibited moderate DPPH scavenging activity, with IC₅₀ values of 6.24 mg/mL and 5.99 mg/mL. The antimutagenic properties were assayed against spontaneous and t-BOOH-induced mutagenesis in Escherichia coli oxyR mutant IC202, a bacterial strain deficient in removing ROS. Reduction of the spontaneous mutagenesis in presence of myrtle EO was only slight, up to 13% at the highest concentration tested. When the oxidative mutagen was used, EO expressed higher reduction of mutagenesis, in a concentration dependent manner, with statistical significance for effect at the highest concentration tested (28%). Suppression of t-BOOH induced mutagenesis was correlated with the observed scavenging activity.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.