Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis

International Journal of Molecular Sciences

Gilles J. P. Rautureau¹  Catherine L. Day² 

[1] Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Australia;Department of Biochemistry, University of Otago, Dunedin 9054, New Zealand

关键词: apoptosis;    Bcl-2;    BH3-only;    intrinsically disordered protein;    protein structure;   

DOI  :  10.3390/ijms11041808

来源: mdpi

【 摘 要 】

Intrinsic cell death is mediated by interaction between pro-apoptotic and pro-survival proteins of the B-cell lymphoma-2 (Bcl-2) family. Members of this family are either intrinsically disordered or contain intrinsically disordered regions/domains that are critical to their function. Alternate splicing and post-translational modifications can determine the extent of these disordered regions and are critical for regulating Bcl-2 proteins. Conformational plasticity and structural transitions characterize the interactions within the Bcl-2 family, with conserved sequence motifs on both binding partners required for their molecular recognition.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.