Maternal Diet, Behaviour and Offspring Skeletal Health

International Journal of Environmental Research and Public Health

Laura R. Goodfellow¹  Susannah Earl¹  Cyrus Cooper¹ 

[1] Medical Research Council Epidemiology Resource Centre, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK;

关键词: osteoporosis;    epigenetic;    early life origins;    fracture;    bone mass;    vitamin D;    neonate;    fetus;   

DOI  :  10.3390/ijerph7041760

来源: mdpi

【 摘 要 】

Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass. Recent work has suggested epigenetic mechanisms as key to these observations. This review will explore the role of the early environment in determining later osteoporotic fracture risk.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.